|ND: Normal Diet; HFD: High Fat Diet; RK: Raspberry Ketone|
Also in 2005, a different research group (associated with DSM, a leading producer of purified nutrients that are used in supplements and food products globally) published a US patent for a neutraceutical blend of the polyphenol found in green tea called EGCG and an RK precursor. This patented product demonstrated the ability to prevent weight gain and obesity associated conditions (like type II diabetes), again, in rodents. Showing similar results, their now patented supplement prevented weight gain in both mice and rats fed a high fat diet or a high fat, high sugar diet.
So, should you be taking RK to get ready for the beach this summer? Well, so far it hasn't been shown to have any adverse effects (other than decreasing the size of your summer beer fund), but because published research in humans is so limited (i.e. non-existent), no one really knows if it is safe. More and more nutrition research is coming out to show that supplementation of large doses of a single nutrient are actually harmful for humans, so you should take caution before popping pills of any kind. Plus keep in mind that RK supplementation has only been shown to prevent rapid weight gain in mice that were eating a very high fat diet, you can't expect that it's going to behave the same in humans that are trying to lose weight. The nutrition community goes through these magical weight loss nutrients so quickly without much to show for it. Remember when I said the idea of using raspberry ketones for weight loss stemmed from using capsaicin for weight loss? Well, do you know anyone that has lost a lot of weight by taking capsaicin pills? Right. I hate to be the negative Nancy here, but the best way to lose weight is really to make some major lifestyle changes that include eating foods that will keep you fuller longer (high fiber, high protein), and constantly reminding yourself to keep moving. Yes, it's going to be hard and you're probably rolling your eyes at the nutrition community for sounding like a broken record, but it is what it is. In the end, you'll be better off trying to increase your intake of raspberries (along with other fruits and vegetables) than spending that cash on pills.
Morimoto, C. et al. Anti-obese action of raspberry ketone. Life Sciences (2005)
Raederstorff, D. et al. Nutraceutical compositions comprising epigallocatechin gallate and raspberry ketone. US Patent Office (2005)